• Drug Addiction and Sexual Dysfunction

    Drug Addiction and Sexual Dysfunction


    Endocrinology and Metabolism Clinics of North America
    Volume 42, Issue 3, September 2013, Pages 585-592

    Authors: Adham Zaazaa, Anthony J. Bella, Rany Shamloul

    Key Points:

    • Even though alcohol is prevalent in many societies with many myths surrounding its sexual-enhancing effects, current scientific research cannot provide a solid conclusion on its effect on sexual function. The same concept applies to tobacco smoking; however, most of the current knowledge tends to support the notion that it, indeed, can negatively affect sexual function. 
    • Cannabinoid receptors in the human cavernous report the nonrelaxing effects of marijuana. 
    • Heroin exerts a depletion effect on plasma levels of free testosterone and raises testosterone-binding globulin levels, irrespective of age, amount of heroin intake per day, and period of contact with the drug with no effect on the pituitary gonadotropins. 
    • Initially, the use of cocaine may enhance the sexual functioning of men, but prolonged use may diminish sexual desire and performance and may contribute to difficulty in achieving orgasm.
    Abstract: Throughout history the search for sex-enhancing drugs or aphrodisiacs has been a human obsession. In a review by Shah, different civilizations’ thoughts and reactions concerning this goal is eloquently discussed.1 For example, poems from the Hindu civilization dating back 3000 to 4000 years are the earliest recordings of the human eternal search for substances that can enhance sexual experiences lead to the much unknown, “supersex,” and/or treat erectile dysfunction (ED).2 The ancient Egyptians had their share of aphrodisiacs with several papyri describing many medications
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